• Frequently Asked Questions

The more patients know about ketamine therapy, the better informed you are to decide if treatment is the right choice for you. We have included some frequently asked questions about ketamine infusion therapy. We want to alleviate any misperceptions or mysteries about the efficacy of the drug in treatment.

At MPH, we aspire to create an environment where every patient feels safe and comfortable. Our clinic is designed to be an attractive, well-appointed medical facility. We want it to feel less like being ‘at the doctor’ and more like you are with friends or family.

Field Anethesia

The History

Ketamine was first synthesized in 1962 by Calvin L. Stevens, a professor of Chemistry at Wayne State University in Detroit, MI. After a lot of very promising research, ketamine was first introduced in controlled human testing in 1964, demonstrating ketamine’s short duration of action and reduced behavioral toxicity, making it a favorable choice over others as a dissociative anesthetic.  Another benefit of ketamine was that is doesn’t lower blood pressure or breathing rates. This, in turn, led to the FDA’s approval in 1970.

Some Americans may know ketamine as a field anesthetic that was used extensively during the Vietnam war to help wounded soldiers on the battlefield. Medics were able to administer ketamine quickly and successfully under difficult circumstances with few adverse side effects. Ketamine is now used daily in U.S. operating and emergency rooms as anesthesia for painful procedures.  It is also the most common anesthetic in third world countries and is listed as one of the World Health Organizations “Essential Medications” due to the high safety profile of this medication.


On a basic neurochemical basis, it is an N-methyl D-aspartate (NMDA) receptor inhibitor.  Blocking the NMDA receptor allows for modulation of glutamate (an excitatory neurotransmitter) and ultimately increases levels of Brain-derived neurotrophic factor (BDNF) and mammalian target of rapamycin (m-TOR), which create protein synthesis in neurons.

Many ketamine experts consider this process a “reset” button for the brain, just like you would reset your computer.  A ketamine infusion allows the unhealthy neuronal pathways that are constantly “on” in your brain to turn off for a period of time.  One can consider all the unhealthy thoughts that continuously occur – such as automatic negative thoughts, obsessive thoughts, anxious thoughts, persistent pain – as these unhealthy pathways.  When your brain comes back “on-line”, you can then access the more healthy pathways or loops in your brain.

Simply put, ketamine works by shutting down overactive neurons while improving the healthy function of the existing neurons. In addition, ketamine improves neural connectivity in the brain that enhances daily, healthy brain function.  Ketamine helps a patient restore executive control of their thoughts and emotions.

Michigan Progressive Health requires a $250 in-person office consultation. This sixty-minute office visit will give ample time for the patient to meet our providers, review risks and benefits of ketamine, answer all questions, and get adequately prepared for the initiation series of ketamine infusions. We are committed to providing each patient with the right tools and resources for success- part of this is presenting alternative therapies that may either compliment or be done instead of ketamine therapy.

To provide you with the highest quality care, maintain confidentiality, and avoid restrictions imposed by insurance companies, we are not in-network with any insurers and collect the full fee at time of service. This allows us to spend more time and direct more attention to you and your care, rather than to meeting insurance company requirements. 

If you have coverage for out-of-network providers, as is typically offered by PPO insurance plans, you might be able to receive some reimbursement for your treatment, though this is not guaranteed and is determined by your insurance provider. After your treatment is rendered, we will provide you with a Superbill at your request that you can submit to your insurance. Payment is due at the time of your visit via cash, check, or credit card.

The cost of each infusion is $500. The number of infusions will differ depending on the patient’s condition and response to initial treatment.

Consultations to begin the treatment process are $250 and require a 50% deposit.

Follow-up Office visits are $150.

MPH Pricing 2022 (Click Here)

MPH looked into many financing companies and chose Walnut as the best possible option for patients. More information can be found at www.hellowalnut.com

MPH looked into many healthcare financing options and chose Walnut as the best option for patients. More information can be found at www.hellowalnut.com 

Please contact MPH with more questions regarding financing.

Ketamine treatment occurs in two steps – “Initiation” and “Maintenance”.

The vast majority of our patients are treated with 6-8 treatments over 3-4 weeks during the initiation phase.

The maintenance period consists of “boosters” – which are typically a single treatment. The first booster is typically scheduled 2-3 weeks after your last initiation infusion. After that, every patient varies, but the average length between boosters is 4-6 weeks.

We find that our patients work with us anywhere from 6 months to 2 years.

For patients with mood disorders, Michigan Progressive Health uses a daily text program to monitor your mood and help decide on timing between infusions.

No, you do not need a referral for treatment here at Michigan Progressive Health.   We evaluate each patient on a case by case basis.  We recommend bringing any records you might have from your psychiatrist, therapist, PCP or pain specialist.  

We do require patients with Major Depression with Psychosis, Bipolar I Disorder and Schizoaffective disorder to have an established relationship with a psychiatrist before starting treatment.

A full and accurate medication and allergy list, and any diagnostic/treatment information from prior physicians. It is recommended that you bring a family member or trusted friend to help you understand if ketamine is right for you.

No. You should continue to take all your medications as scheduled, including your medications for pain and depression. You may find a decreased need for these meds after your infusion; however, you should work with your doctor to wean off these medications instead of stopping quickly.

Please do not have anything to eat four hours prior to your infusion appointment or have anything to drink two hours prior to your appointment.

No. Your thinking may be impaired for up to 24 hours, and we require you to have someone to drive you home BEFORE starting the infusion.  We also ask that you refrain from operating heavy machinery, avoid strenuous activities, do not watch small children or sign/enter into legal contracts for the next 12 hours.

Comfortable, loose clothing.

Yes, MPH is quite comfortable treating teenagers with treatment resistant mood disorders.  We do require our pediatric patients to be working with a therapist and the treating physician must approve of ketamine therapy before treatment can be started.

The patient must have their psychiatric medication prescriber send a referral through our website for the patient to start the treatment process.  The MPH team will then reach out to the provider to determine if the patient might be an appropriate candidate for ketamine therapy.  Our team is happy to share supporting literature with your child’s treatment team.  If it is agreed that your child might benefit from ketamine, our patient coordination staff will reach out to schedule a consultation.

You will be greeted by our office staff and asked to fill out a short questionnaire. The doctor will perform a physical exam. The doctor will start an IV and place you on monitors. We will help you get comfortable and then begin the infusion.  During your infusion you will have your blood pressure, heart rate, oxygen level and breathing monitored.  Typically the infusion lasts one hour, and we monitor you for 15 to 30 minutes after the infusion.

Any severe hypertension, chest pain, evidence of street drug abuse (cocaine, amphetamines or opiates) or manic symptoms during your physical exam will prohibit you from receiving Ketamine.

Currently MPH offers legal psychedelic treatment in the form of ketamine assisted therapy.  We are awaiting the final results from stage 3 FDA trials for MDMA and Psilocybin and hopefully will offer those treatments as they become legal.

MPH strongly recommends that our patients have an active ongoing relationship with a licensed therapist.  Studies have shown that ketamine is more effective when given in the context of therapy.  We do understand that many patients have tried multiple therapy modalities without success prior to seeking treatment with us.  We’ve built a strong and trusted network of mental health professionals that understand ketamine treatment who we can refer you to.